Современные представления об этиологии и патогенезе болезни Паркинсона (обзор)
Статья в журнале
Русский
Библиогр.: с. 27 (33 назв.)
616.858-008.6
болезнь Паркинсона; этиология; патогенез; генетика; демографические факторы, нейротоксины; нейропротекция; убиквитиновая система, митохондриальная дисфункция; окислительный стресс; эксайтотоксичность; Parkinson’sdisease; etiology; pathogenesis; genetics; demographic factors; neurotoxins; neuroprotection; ubiquitin-system; mitochondrial dysfunction; oxidant stress; excitotoxicity
Медицина и здравоохранение / Клиническая медицина / Неврология, Медицина и здравоохранение / Клиническая медицина / Психиатрия и психотерапия
Вестник Северо-Восточного федерального университета им. М. К. Аммосова. – 2016. – N 02 (03)
C. 19-27
Вестник Северо-Восточного федерального университета им. М. К. Аммосова
Якутск, Северо-Восточный федеральный университет
2222-5404 (print)
РИНЦ 2017: 0,237
Parkinson’s disease is one of the most common neurodegenerative disease and found in all countries of the world. The average prevalence of the disease varies from 120 to 180 per 100 thousand population. Parkinson’s disease is disease of the elderly: if up to 45 years, it almost does not occur, then after 60 years of Parkinson’s disease suffers 1-2% of the population, and after 85 years - 3-5%. According to the latest WHO data, in the world of Parkinson’s disease affects more than 4 million people. This indicator will continue to grow and by 2030 will amount to 9 million people. The disease was first described in 1817 by the English surgeon James Parkinson in his “Essay on the Shaking Palsy”. However, until recently, in spite of a breakthrough science are not fully clarified the etiology and pathogenesis of the disease. Parkinson’s disease currently is considered as multifactorial disease and thus, it is intended multifactorial causes, including genetic and environmental factors. However, significant factors affecting the development of the disease is not currently identified. In recent years, widely it begins to studyof impact bowel microbiocenosis on the development of neurodegenerative diseases, including and Parkinson’s disease. The article describes the latest data of the scientific literature on the contribution of genetic, demographic and environmental factors in the development of Parkinson’s disease and discusses the current pathogenic mechanisms
Современные представления об этиологии и патогенезе болезни Паркинсона (обзор) / А. А. Таппахов, Т. Я. Николаева // Вестник Северо-Восточного федерального университета им. М. К. Аммосова. Серия: Медицинские науки.— 2016. — N 2 (03). — С. 19-27.
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